Vitamin D Insufficiency and Severe Asthma Exacerbations in Puerto Rican Children
- 15 July 2012
- journal article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 186 (2), 140-146
- https://doi.org/10.1164/rccm.201203-0431oc
Abstract
Vitamin D insufficiency (a serum 25(OH)D <30 ng/ml) has been associated with severe asthma exacerbations, but this could be explained by underlying racial ancestry or disease severity. Little is known about vitamin D and asthma in Puerto Ricans. To examine whether vitamin D insufficiency is associated with severe asthma exacerbations in Puerto Rican children, independently of racial ancestry, atopy, and time outdoors. A cross-sectional study was conducted of 560 children ages 6-14 years with (n = 287) and without (n = 273) asthma in San Juan, Puerto Rico. We measured plasma vitamin D and estimated the percentage of African racial ancestry among participants using genome-wide genotypic data. We tested whether vitamin D insufficiency is associated with severe asthma exacerbations, lung function, or atopy (greater than or equal to one positive IgE to allergens) using logistic or linear regression. Multivariate models were adjusted for African ancestry, time outdoors, atopy, and other covariates. Vitamin D insufficiency was common in children with (44%) and without (47%) asthma. In multivariate analyses, vitamin D insufficiency was associated with higher odds of greater than or equal to one severe asthma exacerbation in the prior year (odds ratio [OR], 2.6; 95% confidence interval [CI], 1.5-4.9; P = 0.001) and atopy, and a lower FEV(1)/FVC in cases. After stratification by atopy, the magnitude of the association between vitamin D insufficiency and severe exacerbations was greater in nonatopic (OR, 6.2; 95% CI, 2-21.6; P = 0.002) than in atopic (OR, 2; 95% CI, 1-4.1; P = 0.04) cases. Vitamin D insufficiency is associated with severe asthma exacerbations in Puerto Rican children, independently of racial ancestry, atopy, or markers of disease severity or control.Keywords
This publication has 37 references indexed in Scilit:
- Geographic Patterns of Genome Admixture in Latin American MestizosPLoS Genetics, 2008
- The International HapMap Project Web site: Figure 1.Genome Research, 2005
- Predictors of disease severity in children with asthma in Hartford, ConnecticutPediatric Pulmonology, 2005
- Implications of correlations between skin color and genetic ancestry for biomedical researchNature Genetics, 2004
- Household exposure factors, asthma, and school absenteeism in a predominantly Hispanic communityJournal of Exposure Science & Environmental Epidemiology, 2003
- Skin pigmentation, biogeographical ancestry and admixture mappingHuman Genetics, 2003
- Prevalence and Correlates of Asthma in the Puerto Rican Population: Behavioral Risk Factor Surveillance System, 2000Journal of Asthma, 2003
- CDC growth charts: United States.2000
- The Role of Cockroach Allergy and Exposure to Cockroach Allergen in Causing Morbidity among Inner-City Children with AsthmaNew England Journal of Medicine, 1997
- Assessment of habitual sun exposure in adolescents via questionnaire???a comparison with objective measurement using polysulphone badgesMelanoma Research, 1996