Vagal input to the enteric nervous system
Open Access
- 1 December 2000
- Vol. 47 (90004), 30iv-32
- https://doi.org/10.1136/gut.47.suppl_4.iv30
Abstract
The view that the ENS is independent can be traced to several types of observation. Early research on the relationship of the ENS to the central nervous system (CNS) noted that the ENS could support motor activity and a number of local reflexes when the viscera were decentralised or isolated. Langley (1922),1 in his seminal analyses, reinforced the idea of a largely autonomous ENS by noting that the preganglionic axons projecting to the ENS were far outnumbered by the multitude of enteric neurones in the viscera. In the case of the vagus nerve in particular, Langley envisioned a few specialised “mother cells” or “vagal cells” in the ENS that were contacted by preganglionic inputs and that then distributed the relatively small number of inputs to a bigger group of effector neurones within the enteric plexuses. In a related but more modern view, Wood (1987)2 suggested that autonomic preganglionics might project to “command neurones” within the ENS.3 On the sensory side, early observations also noted that individuals with intact peripheral nerves connecting the ENS and CNS had little awareness of visceral afferent feedback.Keywords
This publication has 8 references indexed in Scilit:
- Afferent innervation of gastrointestinal tract smooth muscle by the hepatic branch of the vagus.1997
- Vagal preganglionic projections to the enteric nervous system characterized withPhaseolus vulgaris-leucoagglutininJournal of Comparative Neurology, 1997
- Three-dimensional reconstructions of autonomic projections to the gastrointestinal tractMicroscopy Research and Technique, 1994
- Electrophysiological identification of vagally innervated enteric neurons in guinea pig stomachAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 1992
- Vagal afferent innervation of the rat fundic stomach: Morphological characterization of the gastric tension receptorJournal of Comparative Neurology, 1992
- Topography of efferent vagal innervation of the rat gastrointestinal tractAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1991
- Simultaneous labeling of vagal innervation of the gut and afferent projections from the visceral forebrain with Dil injected into the dorsal vagal complex in the ratJournal of Comparative Neurology, 1990
- Identification of vagal efferent fibers and putative target neurons in the enteric nervous system of the ratJournal of Comparative Neurology, 1989