Intrinsic Human Elimination Half-Lives of Polychlorinated Biphenyls Derived from the Temporal Evolution of Cross-Sectional Biomonitoring Data from the United Kingdom
- 1 February 2011
- journal article
- Published by Environmental Health Perspectives in Environmental Health Perspectives
- Vol. 119 (2), 225-231
- https://doi.org/10.1289/ehp.1002211
Abstract
BACKGROUND: Most empirical estimates of human elimination kinetics for persistent chemicals reflect apparent elimination half-lives that represent the aggregated effect of intrinsic elimination, ongoing exposure, and changes in body weight. However, estimates of intrinsic elimination at background levels are required for risk assessments for the general population. OBJECTIVE: To estimate intrinsic human elimination half-lives at background levels for nine polychlorinated biphenyl (PCB) congeners, we used a novel approach based on population data. METHODS: We used a population pharmacokinetic model to interpret two sets of congener-specific cross-sectional age-concentration biomonitoring data of PCB concentrations measured in lipid and blood samples that were collected from 229 individuals in 1990 and 2003. Our method is novel because it exploits information about changes in concentration in the human population along two dimensions: age and calendar time. RESULTS: Our approach extracted information about both elimination kinetics and exposure trends from biomonitoring data. The longest intrinsic human elimination half-lives estimated in this study are 15.5 years for PCB-170, 14.4 years for PCB-153, and 11.5 years for PCB-180. CONCLUSIONS: Our results are further evidence that a maximum intrinsic elimination half-life for persistent chemicals such as PCBs exists and is approximately 10-15 years. A clear conceptual distinction between apparent and intrinsic half-lives is required to reduce the uncertainty in elimination half-lives of persistent chemicals. The method presented here estimates intrinsic elimination half-lives and the exposure trends of persistent pollutants using cross-sectional data available from a large and growing number of biomonitoring programsKeywords
This publication has 36 references indexed in Scilit:
- Serum Polybrominated Diphenyl Ether (PBDE) Levels Are Higher in Children (2–5 Years of Age) than in Infants and AdultsEnvironmental Health Perspectives, 2009
- A Multi-Individual Pharmacokinetic Model Framework for Interpreting Time Trends of Persistent Chemicals in Human Populations: Application to a Postban SituationEnvironmental Health Perspectives, 2009
- Apparent Half-Lives of Dioxins, Furans, and Polychlorinated Biphenyls as a Function of Age, Body Fat, Smoking Status, and Breast-FeedingEnvironmental Health Perspectives, 2009
- A Physiologically Based Pharmacokinetic Model for the Assessment of Infant Exposure to Persistent Organic Pollutants in Epidemiologic StudiesEnvironmental Health Perspectives, 2009
- Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring ResultsEnvironmental Health Perspectives, 2008
- Physiologically Based Pharmacokinetic Modeling of Persistent OrganicPollutants for Lifetime Exposure Assessment: A New Tool in Breast CancerEpidemiologic StudiesEnvironmental Health Perspectives, 2008
- DDT and Breast Cancer in Young Women: New Data on the Significance of Age at ExposureEnvironmental Health Perspectives, 2007
- Elimination of polychlorinated dibenzofurans (PCDFs) and polychlorinated biphenyls (PCBs) from human blood in the Yusho and Yu-Cheng rice oil poisoningsArchives of Environmental Contamination and Toxicology, 1993
- Propagation of error and bias in half-life estimates based on two measurementsArchives of Environmental Contamination and Toxicology, 1989
- Rate of decrease and half-life of polychlorinated biphenyls (PCBs) in the blood of mothers and their children occupationally exposed to PCBsArchives of Environmental Contamination and Toxicology, 1984