Choroid Plexus in the Central Nervous System: Biology and Physiopathology
Open Access
- 1 July 2000
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Neuropathology and Experimental Neurology
- Vol. 59 (7), 561-574
- https://doi.org/10.1093/jnen/59.7.561
Abstract
Choroid plexuses (CPs) are localized in the ventricular system of the brain and form one of the interfaces between the blood and the central nervous system (CNS). They are composed of a tight epithelium responsible for cerebrospinal fluid secretion, which encloses a loose connective core containing permeable capillaries and cells of the lymphoid lineage. In accordance with its peculiar localization between 2 circulating fluid compartments, the CP epithelium is involved in numerous exchange processes that either supply the brain with nutrients and hormones, or clear deleterious compounds and metabolites from the brain. Choroid plexuses also participate in neurohumoral brain modulation and neuroimmune interactions, thereby contributing greatly in maintaining brain homeostasis. Besides these physiological functions, the implication of choroid plexuses in pathological processes is increasingly documented. In this review, we focus on some of the novel aspects of CP functions in relation to brain development, transfer of neuro-humoral information, brain/immune system interactions, brain aging, and cerebral pharmaco-toxicology.Keywords
This publication has 69 references indexed in Scilit:
- Ultrastructural localization of adhesion molecules in the healthyCell and tissue research, 1999
- Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparationsJournal of Comparative Neurology, 1999
- Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In VitroThe Journal of cell biology, 1998
- Fate of Cerebrospinal Fluid‐Borne Amyloid β‐Peptide: Rapid Clearance into Blood and Appreciable Accumulation by Cerebral ArteriesJournal of Neurochemistry, 1996
- Influence of the choroid plexus on cerebellar development: analysis of retinoic acid synthesisDevelopmental Brain Research, 1996
- N‐System Amino Acid Transport at the Blood‐CSF BarrierJournal of Neurochemistry, 1995
- Regulation of Neuronal Differentiation by Retinoic Acid Alone and in Cooperation with Thyroid Hormone or HydrocortisoneDevelopmental Neuroscience, 1993
- Effects of perinatal hypo- and hyperthyroidism on the levels of nerve growth factor and its low-affinity receptor in cerebellumDevelopmental Brain Research, 1993
- A morphometric study on the development of the lateral ventricle choroid plexus, choroid plexus capillaries and ventricular ependyma in the ratDevelopmental Brain Research, 1990
- Retinoic Acid EmbryopathyNew England Journal of Medicine, 1985