Low Sensitivity of a Whole‐Blood Interferon‐γ Release Assay for Detection of Active Tuberculosis
Open Access
- 1 January 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 44 (1), 69-73
- https://doi.org/10.1086/509928
Abstract
The sensitivity of an interferon-γ assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%–78%) of 36 subjects had positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.Keywords
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