Low-tidal-volume Mechanical Ventilation Induces a Toll-like Receptor 4–dependent Inflammatory Response in Healthy Mice
- 1 September 2008
- journal article
- critical care-medicine
- Published by Ovid Technologies (Wolters Kluwer Health) in Anesthesiology
- Vol. 109 (3), 465-472
- https://doi.org/10.1097/aln.0b013e318182aef1
Abstract
MECHANICAL ventilation (MV) facilitates surgical interventions during general anesthesia and is a lifesaving intervention in acute respiratory failure. However, MV can induce lung injury; this has been termed ventilator-induced lung injury (VILI).1 VILI can exacerbate damage in the already injured lung but can also occur in healthy lung.2 The mechanisms of VILI are incompletely understood, but a role for proinflammatory pathways has been proposed.3Keywords
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