Immune response induced by New World Leishmania species in C57BL/6 mice
- 1 September 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Zeitschrift für Parasitenkunde
- Vol. 94 (3), 207-212
- https://doi.org/10.1007/s00436-004-1193-6
Abstract
In the present study, C57BL/6 mice were inoculated with metacyclic Leishmania amazonensis or L. braziliensis promastigotes. While these animals were capable of controlling the infection by L. braziliensis, they developed chronic lesions with elevated numbers of parasites when infected by L. amazonensis. The differences in parasite control were associated with a decreased production of IFN-γ and TNF by lymph node cells from L. amazonensis-infected mice. Furthermore, these animals presented decreased spleen cell proliferation and activation of germinal centers. In addition, we compared the ability of these parasites to hydrolyze extracellular ATP and AMP. While the ATPase activity of both parasite species was similar, L. amazonensis promastigotes presented higher AMP hydrolytic activity. This increased activity may lead to an increased production of adenosine, which has been shown to present anti-inflammatory activity and may thus be involved in the establishment of the immunosuppression observed in mice infected by L. amazonensis.This publication has 45 references indexed in Scilit:
- Characterization and immunolocalization of an NTP diphosphohydrolase of Trypanosoma cruziBiochemical and Biophysical Research Communications, 2004
- Impaired Expression of Inflammatory Cytokines and Chemokines at Early Stages of Infection withLeishmania amazonensisInfection and Immunity, 2003
- Metabolic Control of Excessive Extracellular Nucleotide Accumulation by CD39/Ecto-Nucleotidase-1: Implications for Ischemic Vascular DiseasesJournal of Pharmacology and Experimental Therapeutics, 2003
- The immunology of susceptibility and resistance to Leishmania major in miceNature Reviews Immunology, 2002
- Immunochemotherapy in American cutaneous leishmaniasis: immunological aspects before and after treatmentMemórias do Instituto Oswaldo Cruz, 2001
- Genetically resistant mice lacking interleukin‐12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell responseEuropean Journal of Immunology, 1996
- Disruption of CD40–CD40 Ligand Interactions Results in an Enhanced Susceptibility to Leishmania amazonensis InfectionImmunity, 1996
- Resistance to murine cutaneous leishmaniasis is mediated by TH1 cells, but disease-promoting CD4+ cells are different from TH2 cellsEuropean Journal of Immunology, 1990
- The role of TH1 and TH2 cells in experimental cutaneous leishmaniasisExperimental Parasitology, 1989
- Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.The Journal of Experimental Medicine, 1989