Neuroprotection by Sodium Channel Blockade with Phenytoin in an Experimental Model of Glaucoma

Abstract

Purpose. Sustained influx of intracellular sodium through voltage-gated sodium channels is an important event in the cascade leading to degeneration of axons. This study tested the hypothesis that sodium channel blockade with phenytoin would result in neuroprotection of retinal ganglion cells (RGCs) and optic nerve axons in an experimental model of glaucoma.