ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia

Abstract
Key Points ABT-199, a new Bcl-2–specific BH3 mimetic, is efficacious in vivo against mouse lymphomas without provoking thrombocytopenia. Treating mouse lymphomas with BH3 mimetic ABT-737 combined with bortezomib or purvalanol achieved long-term remission.