Mollamides B and C, Cyclic Hexapeptides from the Indonesian Tunicate Didemnum molle
Open Access
- 1 June 2008
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 71 (6), 941-945
- https://doi.org/10.1021/np700718p
Abstract
Two new cyclic hexapeptides, mollamides B (1) and C (2), were isolated from the Indonesian tunicate Didemnum molle along with the known peptide keenamide A (3). The structures were established using 1D and 2D NMR experiments. The relative configuration of mollamide B at the thiazoline moiety was determined using molecular modeling coupled with NMR-derived restraints. Their absolute configuration was determined using Marfeyʼs method. The new peptides have been evaluated for their antimicrobial, antimalarial, anticancer, anti-HIV-1, anti-Mtb, and anti-inflammatory activities. Keenamide A and mollamide B show cytotoxicity against several cancer cell lines.Keywords
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