Obesity and respiratory diseases
Open Access
- 1 October 2010
- journal article
- review article
- Published by Taylor & Francis Ltd in International Journal of General Medicine
- Vol. 3, 335-343
- https://doi.org/10.2147/ijgm.s11926
Abstract
Abstract: The obesity epidemic is a global problem, which is set to increase over time. However, the effects of obesity on the respiratory system are often underappreciated. In this review, we will discuss the mechanical effects of obesity on lung physiology and the function of adipose tissue as an endocrine organ producing systemic inflammation and effecting central respiratory control. Obesity plays a key role in the development of obstructive sleep apnea and obesity hypoventilation syndrome. Asthma is more common and often harder to treat in the obese population, and in this study, we review the effects of obesity on airway inflammation and respiratory mechanics. We also discuss the compounding effects of obesity on chronic obstructive pulmonary disease (COPD) and the paradoxical interaction of body mass index and COPD severity. Many practical challenges exist in caring for obese patients, and we highlight the complications faced by patients undergoing surgical procedures, especially given the increased use of bariatric surgery. Ultimately, a greater understanding of the effects of obesity on the respiratory disease and the provision of adequate health care resources is vital in order to care for this increasingly important patient population.Keywords
This publication has 64 references indexed in Scilit:
- Update in Sleep Medicine 2009American Journal of Respiratory and Critical Care Medicine, 2010
- Losing weight in moderate to severe obstructive sleep apnoeaBMJ, 2009
- Ventilación mecánica no invasiva en la Comunidad Valenciana: de la teoría a la prácticaArchivos de Bronconeumología, 2009
- Obesity and respiratory diseasesChronic Respiratory Disease, 2008
- A Possible Association Between Suspected Restrictive Pattern as Assessed by Ordinary Pulmonary Function Test and the Metabolic SyndromeSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2008
- Effect of Serum Leptin Levels on Hypercapnic Ventilatory Response in Obstructive Sleep ApneaRespiration, 2007
- Relationship of Dyspnea to Respiratory Drive and Pulmonary Function Tests in Obese Patients Before and After Weight LossSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2005
- The effects of body weight on airway calibreEuropean Respiratory Journal, 2005
- Leptin Prevents Respiratory Depression in ObesityAmerican Journal of Respiratory and Critical Care Medicine, 1999
- Current views on obesityThe American Journal of Medicine, 1996