Pathogenesis of experimental bovine spongiform encephalopathy (BSE): estimation of tissue infectivity according to incubation period
Open Access
- 28 October 2008
- journal article
- Published by EDP Sciences in Veterinary Research
- Vol. 40 (1), 1
- https://doi.org/10.1051/vetres:2008046
Abstract
International audienceThis paper reports the results of tissue infectivity assays of bovine spongiform encephalopathy (BSE) agent in orally exposed cattle at stages during the incubation period. Estimations of the titre of infectivity in central nervous system (CNS), certain peripheral nerve ganglia and distal ileum tissue were made according to time post exposure from the relationship between incubation period and dose for RIII mice and C57bl mice using data from titrations of brain material from cases of BSE. The rate of increase of infectivity in the bovine CNS was then estimated, taking into account these tissue infectivity titres, the variability of the brain titre of clinical field cases of BSE, and the probability density of the expected number of months before clinical onset of each infected bovine. The doubling time for CNS was shown to equal 1.2 months. The titre in the thoracic dorsal root ganglia (DRG) was, on average, approximately 1 log units less than CNS, and cervical DRG approximately 0.5 log less than thoracic DRG. The pattern of increase of infectivity in the distal ileum is that of an initial increase up to 14-18 months post exposure, followed by a decrease, which is likely to be highly variable between animals. These results will be informative for future risk assessments of BSE, especially in relation to reviewing current control measuresKeywords
This publication has 33 references indexed in Scilit:
- Review on the epidemiology and dynamics of BSE epidemicsVeterinary Research, 2008
- Estimating the temporal relationship between PrPSc detection and incubation period in experimental bovine spongiform encephalopathy of cattleJournal of General Virology, 2007
- Highly Bovine Spongiform Encephalopathy–Sensitive Transgenic Mice Confirm the Essential Restriction of Infectivity to the Nervous System in Clinically Diseased CattleThe Journal of Infectious Diseases, 2005
- Exposure of the human population to BSE infectivity over the course of the BSE epidemic in Great Britain and the impact of changes to the Over Thirty Month RuleJournal of Risk Research, 2004
- Assessment of the risk posed by bovine spongiform encephalopathy in cattle in Great Britain and the impact of potential changes to current control measuresProceedings. Biological sciences, 2003
- Quantifying BSE control by calculating the basic reproduction ratio R 0 for the infection among cattleJournal of Mathematical Biology, 2003
- Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapieJournal of General Virology, 1996
- Pathogenesis of Scrapie: Study of the Temporal Development of Clinical Symptoms, of Infectivity Titres and Scrapie-associated Fibrils in Brains of Hamsters Infected IntraperitoneallyJournal of General Virology, 1986
- Genetical control of the concentration of ME7 scrapie agent in the brain of miceJournal of Comparative Pathology, 1969
- Identification of a gene which controls the incubation period of some strains of scrapie agent in miceJournal of Comparative Pathology, 1968