Can structural MRI indices of cerebral integrity track cognitive trends in executive control function during normal maturation and adulthood?
Open Access
- 9 December 2008
- journal article
- research article
- Published by Wiley in Human Brain Mapping
- Vol. 30 (8), 2581-2594
- https://doi.org/10.1002/hbm.20689
Abstract
We explored the relationship between structural neuroimaging‐based indices of cerebral integrity and executive control function (ECF) in two groups of healthy subjects: A maturing group (33 subjects; 19–29 years) and a senescing group (38 adults; 30–90 years). ECF was assessed using the Executive Interview (EXIT) battery. Cortical indices of cerebral integrity included GM thickness, intergyral span, and sulcal span, each measured for five cortical regions per hemisphere. Subcortical indices included fractional anisotropy (FA), measured using track‐based‐spatial‐statistics (TBSS), and the volume of T2‐hyperintense WM (HWM). In the maturing group, no significant relationships between neuroanatomical changes and ECF were found; however, there were hints that late‐term maturation of cerebral WM influenced variability in ECF. In the senescing group, the decline in ECF corresponded to atrophic changes in cerebral WM (sulcal and intergyral span) primarily in the superior frontal and anterior cingulate regions. A large fraction of the variability in ECF (62%) can be explained by variability in the structural indices from these two regions. Hum Brain Mapp 2009.Keywords
This publication has 77 references indexed in Scilit:
- Relationship among neuroimaging indices of cerebral health during normal agingHuman Brain Mapping, 2007
- Age effects on atrophy rates of entorhinal cortex and hippocampusNeurobiology of Aging, 2006
- Assessment of in vivo MR imaging compared to physical sections in vitro—A quantitative study of brain volumes using stereologyNeuroImage, 2005
- Exploring the unity and diversity of the neural substrates of executive functioningHuman Brain Mapping, 2005
- Mapping structural differences of the corpus callosum in individuals with 18q deletions using targetless regional spatial normalizationHuman Brain Mapping, 2005
- Pathological Aging of the BrainTopics in Magnetic Resonance Imaging, 2004
- Applications of diffusion‐weighted and diffusion tensor MRI to white matter diseases – a reviewNMR in Biomedicine, 2002
- From 3D magnetic resonance images to structural representations of the cortex topography using topology preserving deformationsJournal of Mathematical Imaging and Vision, 1995
- The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger’s ReportStroke, 1995
- Bedside assessment of frontal degeneration: Distinguishing alzheimer's disease from non-alzheimer's cortical dementiaExperimental Aging Research, 1994