Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited
Open Access
- 14 April 2010
- journal article
- Published by The Royal Society in Biology Letters
- Vol. 6 (5), 696-698
- https://doi.org/10.1098/rsbl.2010.0152
Abstract
Biological rhythms that oscillate with periods close to 24 h (circadian cycles) are pervasive features of mammalian physiology, facilitating entrainment to the 24 h cycle generated by the rotation of the Earth. In the absence of environmental time cues, circadian rhythms default to their endogenous period called tau , or the free-running period. This sustained circadian rhythmicity in constant conditions has been reported across the animal kingdom, a ubiquity that could imply that innate rhythmicity confers an adaptive advantage. In this study, we found that the deviation of tau from 24 h was inversely related to the lifespan in laboratory mouse strains, and in other rodent and primate species. These findings support the hypothesis that misalignment of endogenous rhythms and 24 h environmental cycles may be associated with a physiological cost that has an effect on longevity.This publication has 23 references indexed in Scilit:
- Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiologyNature, 2008
- Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamstersAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2008
- Correlative association between circadian expression of mousePer2 gene and the proliferation of the neural stem cellsNeuroscience, 2007
- Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferationProceedings of the National Academy of Sciences of the United States of America, 2007
- Comparison of clock gene expression in SCN, retina, heart, and liver of miceBiochemical and Biophysical Research Communications, 2006
- Plant Circadian Clocks Increase Photosynthesis, Growth, Survival, and Competitive AdvantageScience, 2005
- BMAL1 and CLOCK, Two Essential Components of the Circadian Clock, Are Involved in Glucose HomeostasisPLoS Biology, 2004
- Coordination of circadian timing in mammalsNature, 2002
- Extensive and divergent circadian gene expression in liver and heartNature, 2002
- Longevity among blowfliesPhormia terraenovae R.D. kept in non-24-hour light-dark cyclesJournal of Comparative Physiology A, 1978