Cytolethal Distending Toxin Gene Cluster in Enterohemorrhagic Escherichia coli O157:H − and O157:H7: Characterization and Evolutionary Considerations
- 1 June 2003
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (6), 3634-3638
- https://doi.org/10.1128/iai.71.6.3634-3638.2003
Abstract
We identified a cytolethal distending toxin ( cdt ) gene cluster in 87, 6, and 0% of sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:H − , EHEC O157:H7, and E . coli O55:H7/H − strains, respectively. The toxin was expressed by the wild-type EHEC O157 strains and by a cdt -containing cosmid from a library of SF EHEC O157:H − strain 493/89. The cdt flanks in strain 493/89 were homologous to bacteriophages P2 and lambda. Our data demonstrate that cdt , encoding a potential virulence factor, is present in the EHEC O157 complex and suggest that cdt may have been acquired by phage transduction.Keywords
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