Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt–β-catenin signaling
Open Access
- 7 March 2013
- journal article
- Published by American Society of Hematology in Blood
- Vol. 121 (10), 1824-1838
- https://doi.org/10.1182/blood-2012-02-412890
Abstract
Key Points Bone marrow mesenchymal stromal cells preserve CML stem cells from elimination following tyrosine kinase inhibitor treatment. N-cadherin and Wnt signaling contribute to protection of CML stem cells by mesenchymal cells and may represent new treatment targets.Keywords
This publication has 50 references indexed in Scilit:
- β-catenin is involved in N-cadherin–dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1–positive B acute lymphoblastic leukemia cellsExperimental Hematology, 2009
- Wnt-Related Molecules and Signaling Pathway Equilibrium in HematopoiesisCell Stem Cell, 2009
- Effects of Dasatinib on Src Kinase Activity and Downstream Intracellular Signaling in Primitive Chronic Myelogenous Leukemia Hematopoietic CellsCancer Research, 2008
- BCR-ABL-transformed GMP as myeloid leukemic stem cellsProceedings of the National Academy of Sciences of the United States of America, 2008
- Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistanceMolecular Cancer Therapeutics, 2008
- β-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemiaLeukemia, 2008
- N-Cadherin Expression Level Distinguishes Reserved versus Primed States of Hematopoietic Stem CellsCell Stem Cell, 2008
- CXCR4 up-regulation by imatinib induces chronic myelogenous leukemia (CML) cell migration to bone marrow stroma and promotes survival of quiescent CML cellsMolecular Cancer Therapeutics, 2008
- Assaying β-Catenin/TCF Transcription with β-Catenin/TCF Transcription-Based Reporter ConstructsPublished by Springer Science and Business Media LLC ,2008
- Targeting of CD44 eradicates human acute myeloid leukemic stem cellsNature Medicine, 2006