Serious Fatal and Nonfatal Non-AIDS-Defining Illnesses in Europe
- 1 October 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in JAIDS Journal of Acquired Immune Deficiency Syndromes
- Vol. 55 (2), 262-270
- https://doi.org/10.1097/qai.0b013e3181e9be6b
Abstract
Background: Little is known about the incidence and risk factors for serious non-AIDS-defining events. Methods: The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated; Poisson regression was used to investigate factors associated with non-AIDS and AIDS. Results: Among 12,844 patients, 1058 were diagnosed with a non-AIDS event [incidence 1.77 per 100 person-years of follow-up; 95% confidence interval (CI): 1.66 to 1.87]; 462 patients (43.7%) died. The incidence of AIDS (1025 diagnoses; 339 deaths, 33.1%) was 1.72 per 100 person-years of follow-up (1.61 to 1.83). After adjustment, older age [incidence rate ratio (IRR): 1.71 per 10 years older, 95% CI: 1.60 to 1.83], diabetes (IRR: 1.49, 95% CI: 1.22 to 1.82) and hypertension (IRR: 1.63, 95% CI: 1.43 to 1.87) were associated with non-AIDS events. Compared with patients without an event, there was a 4-fold increased risk of death after an AIDS event (relative hazard: 4.14; 95% CI 3.47 to 4.94) and almost a 7-fold increased risk of death after a non-AIDS event (relative hazard: 6.72; 95% CI: 5.61 to 8.05). Conclusions: Non-AIDS events were common in the combination antiretroviral therapy era and associated with considerably mortality. Evidence on the impact of modifying immunodeficiency and lifestyle-related factors on the risk of non-AIDS events in HIV-infected persons is an important but unmet research need.Keywords
This publication has 50 references indexed in Scilit:
- Causes of Death in HIV‐1–Infected Patients Treated with Antiretroviral Therapy, 1996–2006: Collaborative Analysis of 13 HIV Cohort StudiesClinical Infectious Diseases, 2010
- Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort studyThe Lancet Oncology, 2009
- Interleukin-2 Therapy in Patients with HIV InfectionThe New England Journal of Medicine, 2009
- Variable Impact on Mortality of AIDS‐Defining Events Diagnosed during Combination Antiretroviral Therapy: Not All AIDS‐Defining Conditions Are Created EqualClinical Infectious Diseases, 2009
- Trends in the incidence of cancers among HIV-infected persons and the impact of antiretroviral therapy: a 20-year cohort studyAIDS, 2009
- The role of HIV in serious diseases other than AIDSAIDS, 2008
- HIV-induced immunodeficiency and mortality from AIDS-defining and non-AIDS-defining malignanciesAIDS, 2008
- Rate of Comorbidities Not Related to HIV Infection or AIDS among HIV‐Infected Patients, by CD4 Cell Count and HAART Use StatusClinical Infectious Diseases, 2008
- CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infectionAIDS, 2008
- Efficacy and Safety of Tenofovir DF vs Stavudine in Combination Therapy in Antiretroviral-Naive PatientsA 3-Year Randomized TrialJAMA, 2004