Effect of Oral OPC-28326, a Selective Femoral Arterial Vasodilator, on Hindlimb Subcutaneous Tissue Temperature in Conscious Dogs Under Buprenorphine Sedation
Open Access
- 1 January 2002
- journal article
- Published by Elsevier BV in The Japanese Journal of Pharmacology
- Vol. 88 (1), 119-122
- https://doi.org/10.1254/jjp.88.119
Abstract
In dogs, rectal temperature was decreased to about 36°C at 2 to 2.5 h after sedation with buprenorphine (0.3 mg/body, i.m.), and hindlimb subcutaneous tissue temperature (TSC) in the thigh decreased in a similar manner. TSC in the dorsum of the foot showed a greater decrease than that in the thigh. OPC-28326 (4-(N-methyl-2-phenylethylamino)-1-(3,5-dimethyl-4-propionyl-aminobenzoyl) piperidine hydrochloride monohydrate) at doses of 0.3, 1.0 and 3.0 mg/kg, p.o. inhibited the buprenorphine-induced decrease in TSC in the dorsum dose-dependently, but had little effect on that in the thigh or rectal temperature. In conclusion, TSC in the extremities were more sensitive to core temperature and peripheral circulation.Keywords
This publication has 2 references indexed in Scilit:
- α2‐adrenoceptor antagonist properties of OPC‐28326, a novel selective peripheral vasodilatorBritish Journal of Pharmacology, 2001
- Pharmacological properties of buprenorphine, a new analgesic agent. Part IIFolia Pharmacologica Japonica, 1982