UVB Exposure Impairs Immune Responses After Hepatitis B Vaccination in Two Different Mouse Strains¶
- 1 January 2002
- journal article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 75 (5), 541-546
- https://doi.org/10.1562/0031-8655(2002)075<0541:ueiira>2.0.co;2
Abstract
Ultraviolet light exposure can impair immune responses that are not restricted to the exposed skin but is also found at other sites, i.e. systemic immunosuppression. Therefore, we investigated the UV‐induced modulating effects on vaccination against hepatitis B in a mouse model. Two different mouse strains, BALB/c and C57Bl/6, were vaccinated intramuscularly against hepatitis B. Mice were exposed to different doses of ultraviolet B (UVB) for five consecutive days on shaved back skin before the vaccination. Vaccination against hepatitis B induced cellular (delayed‐type hypersensitivity [DTH] and lymphocyte stimulation test) as well as humoral immune responses in both mouse strains. The DTH responses in C57Bl/6 mice were statistically significantly higher compared with BALB/c mice. UVB exposure induced a dose‐dependent suppression of cellular immunity in both strains of mice. C57Bl/6 mice seemed to be more susceptible to this suppression. Anti‐hepatitis B surface antibodies (total‐Ig) were only marginally suppressed after UVB exposure. IgG2a and interferon‐γ levels, both indicators for Th1 immune response, were suppressed in both mouse strains after UVB exposure. In summary, UVB exposure induced a dose‐dependent suppression of both cellular and humoral immune responses after hepatitis B vaccination, although the suppressive effects on humoral immunity were limited to IgG2a production. Susceptibility to UVB‐induced immunomodulation depended on the strain of mice and their predilection for developing different T cell responses.This publication has 26 references indexed in Scilit:
- UV Exposure Alters Respiratory Allergic Responses in Mice¶Photochemistry and Photobiology, 2000
- UVB exposure‐induced systemic modulation of Th1‐ and Th2‐mediated immune responsesImmunology, 1999
- A Role for Neuropeptides in UVB‐Induced Systemic ImmunosuppressionPhotochemistry and Photobiology, 1998
- UVB‐lnduced Decreased Resistance to Trichinella spiralis in the Rat Is Related to Impaired Cellular ImmunityPhotochemistry and Photobiology, 1996
- Effects of Ultraviolet‐B Exposure on the Resistance to Listeria monocytogenes in the RatPhotochemistry and Photobiology, 1996
- HYDROGEN PEROXIDE MEDIATES UV‐INDUCED IMPAIRMENT OF ANTIGEN PRESENTATION IN A MURINE EPIDERMAL‐DERIVED DENDRITIC CELL LINEPhotochemistry and Photobiology, 1995
- UVB Light Induces Nuclear Factor κB (NFκB) Activity Independently from Chromosomal DNA Damage in Cell-Free Cytosolic ExtractsJournal of Investigative Dermatology, 1994
- UV-B exposure impairs resistance to infection by Trichinella spiralis.Environmental Health Perspectives, 1994
- Immunosuppression by ultraviolet B radiation: initiation by urocanic acidImmunology Today, 1992
- Lymphokine Control of In Vivo Immunoglobulin Isotype SelectionAnnual Review of Immunology, 1990