Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack
Open Access
- 1 September 2021
- journal article
- research article
- Published by BMJ in Stroke and Vascular Neurology
- Vol. 6 (3), 458-466
- https://doi.org/10.1136/svn-2020-000676
Abstract
Background To examine the relationship of serum albumin with poor functional outcome and mortality in patients with acute ischaemic stroke (AIS) or transient ischaemic attack (TIA), and perform a meta-analysis to summarise the association. Methods We analysed data from the Third China National Stroke Registry (CNSR-III). Patients were divided into four groups based on serum albumin levels at admission. The outcomes included poor functional outcome (modified Rankin Scale (mRS) score of 3 to 6) and mortality at 3 months and 1 year. Multiple logistic regression models and Cox regression models were used to evaluate the association, respectively. We used a fixed-effect model to calculate the risk ratio for poor functional outcome and a random-effect model for mortality in the meta-analysis. Results A total of 13 618 patients were enrolled. During the 3-month follow-up period, compared with 40 to 44.9 g/L group, patients in <35 g/L group had an increased risk of poor functional outcome and mortality (adjusted OR 1.37 (95% CI 1.12 to 1.67); adjusted HR 2.13 (95% CI 1.41 to 3.23)). The relationship in per 10 g/L decreased serum albumin with prognosis was consistently inversed (adjusted OR 1.17 (95% CI 1.01 to 1.35); adjusted HR 1.86 (95% CI 1.30 to 2.64)). Also, low serum albumin levels were independently correlated with clinical outcomes at 1 year. In the meta-analysis, the OR for poor functional outcome pooled 3 studies per 1 g/L decrease was 1.03 (95% CI 1.02 to 1.05), and the HR for mortality pooled 5 studies was 1.07 (95% CI 1.03 to 1.11). Conclusions Low serum albumin levels predict poor functional outcome and mortality in patients with AIS or TIA.Funding Information
- Beijing Municipal Science & Technology Commission (Z181100001818001)
- beijing excellent talents training program (2018000021469G234)
- Beijing Municipal Administration of Hospitals Incubating Program (PX2020021)
- National Natural Science Foundation of China (81870905)
- National Key R&D Program of China (2018YFC1312903)
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