Solitary Fibrous Tumor of the Thyroid Gland
- 1 November 2001
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Surgical Pathology
- Vol. 25 (11), 1424-1428
- https://doi.org/10.1097/00000478-200111000-00011
Abstract
Solitary fibrous tumor is a soft tissue neoplasm initially described in the pleura but subsequently reported in a wide variety of locations. The clinical behavior is usually benign, but the existence of aggressive cases has been documented both in the pleura and in extrapleural sites. In this report clinical and pathologic features of seven solitary fibrous tumors of the thyroid gland are presented. Patients' ages ranged from 43 to 64 years (mean 52 years), and tumor sizes varied from 2 to 6 cm. Grossly, the tumors were white–tan and well circumscribed. Microscopically, there was a variegated, wavy, storiform, hemangiopericytic or desmoid-like arrangement of spindle cells. Trapped thyroid follicles within the tumor and peripheral jagged tumor infiltration among follicles were common. There was immunohistochemical reactivity for CD34, CD99, and bcl-2, and ultrastructural analysis of one tumor was consistent with a fibroblastic lineage. The differential diagnosis included other benign and malignant mesenchymal tumors of the thyroid, spindle cell follicular adenoma, Riedel's thyroiditis, the spindle cell, and paucicellular variants of anaplastic carcinoma, papillary thyroid carcinoma with exuberant nodular fasciitis-like stroma, and the spindle epithelial tumor with thymus-like differentiation. The cumulative data of 13 cases (comprised of the seven present cases and the six previously reported) suggest a benign clinical behavior for thyroid SFT.Keywords
This publication has 33 references indexed in Scilit:
- Solitary fibrous tumour — everywhere, and a diagnosis in vogueHistopathology, 1997
- Solitary fibrous tumorCancer, 1997
- bcl-2 EXPRESSION IN PLEURAL AND EXTRAPLEURAL SOLITARY FIBROUS TUMOURSThe Journal of Pathology, 1997
- Solitary Fibrous Tumor of the Meninges: A Lesion Distinct From Fibrous Meningioma:A Clinicopathologic and Immunohistochemical StudyAmerican Journal of Clinical Pathology, 1996
- CD34 and Thyroid Fibrous TumorThe American Journal of Surgical Pathology, 1995
- Solitary Fibrous Tumor of the ThyroidAmerican Journal of Clinical Pathology, 1994
- Solitary Fibrous Tumor of the OrbitThe American Journal of Surgical Pathology, 1994
- Tumors of the neck showing thymic or related branchial pouch differentiation: A unifying conceptHuman Pathology, 1991
- Papillary Carcinoma of Thyroid with Exuberant Nodular Fasciitis-like Stroma: Report of Three CasesAmerican Journal of Clinical Pathology, 1991
- Solitary fibrous tumors of the pleura: Eight new cases and review of 360 cases in the literatureCancer, 1981