rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.
Open Access
- 1 February 1990
- journal article
- Published by Cold Spring Harbor Laboratory in Genes & Development
- Vol. 4 (2), 190-203
- https://doi.org/10.1101/gad.4.2.190
Abstract
Rhomboid (rho) belongs to a group of four genes involved in the elaboration of positional information at a ventrolateral level in the Drosophila embryo. Mutations at any of these four loci also lead to a variety of other phenotypes, including reduction in the number of stretch receptor organs (chordotonal organs) in the peripheral nervous system (PNS). We have cloned rho with the aid of a lacZ-bearing P-element inserted into the rho gene. In the early blastoderm stage, a putative rho transcript is expressed in ventrolateral strips corresponding to the domain of activity of the rho gene on the embryonic fate map. Later expression of the transcript correlates with regions of the embryo that are disrupted in rho mutants and includes a cell that may be the precursor for the missing stretch receptor organs. We hypothesize that rho acts very early in differentiation pathways to specify the identities of domains and isolated precursor cells. Sequence analysis suggests that this transcript codes for a trans-membrane protein.Keywords
This publication has 39 references indexed in Scilit:
- P-element-mediated enhancer detection: a versatile method to study development in Drosophila.Genes & Development, 1989
- Searching for pattern and mutation in the Drosophila genome with a P-lacZ vector.Genes & Development, 1989
- The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.Genes & Development, 1988
- A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradationCell, 1986
- Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22Cell, 1986
- A conformational preference parameter to predict helices in integral membrane proteinsBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986
- Establishment of dorsal-ventral polarity in the drosophila embryo: The induction of polarity by the Toll gene productCell, 1985
- Establishment of dorsal-ventral polarity in the Drosophila embryo: Genetic studies on the role of the Toll gene productCell, 1985
- The detection and classification of membrane-spanning proteinsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1985
- Analysis of membrane and surface protein sequences with the hydrophobic moment plotJournal of Molecular Biology, 1984