Defining mild cognitive impairment in Parkinson's disease
- 5 April 2007
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 22 (9), 1272-1277
- https://doi.org/10.1002/mds.21453
Abstract
Our purpose was to characterize a state of mild cognitive impairment (MCI) in Parkinson's disease (PD) (PD-MCI) that would be analogous to the MCI that is posited as a precursor of Alzheimer's disease (AD). We categorized 86 PD subjects in a brain bank population as either cognitively normal (PD-CogNL), PD-MCI using criteria that included a 1.5 standard deviation or greater deficit upon neuropsychological testing consistently across at least one cognitive domain without dementia, and PD dementia (PD-D) using DSM-IV criteria. Twenty-one percent of our PD sample met criteria for PD-MCI, 62% were PD-CogNL, and 17% had PD-D. The mean duration of PD and MMSE scores of the PD-MCI group were intermediate and significantly different from both PD-CogNL and PD-D. The cognitive domain most frequently abnormal in PD-MCI was frontal/executive dysfunction followed by amnestic deficit. Single domain PD-MCI was more common than PD-MCI involving multiple domains. We conclude that a stage of clinical cognitive impairment in PD exists between PD-CogNL and PD-D, and it may be defined by applying criteria similar to the MCI that is posited as a precursor of AD. Defining PD-MCI offers an opportunity for further study of cognitive impairment in PD and targets for earlier therapeutic intervention. © 2007 Movement Disorder SocietyKeywords
This publication has 25 references indexed in Scilit:
- Subtypes of mild cognitive impairment in parkinson's disease: Progression to dementiaMovement Disorders, 2006
- Risk and incidence of dementia in a cohort of older subjects with Parkinson's disease in the United KingdomMovement Disorders, 2004
- Memory and executive function impairment predict dementia in Parkinson's diseaseMovement Disorders, 2002
- Neuropsychological tests' norms above age 55: COWAT, BNT, MAE token, WRAT-R reading, AMNART, STROOP, TMT, and JLOThe Clinical Neuropsychologist, 1996
- Screening for dementia of the alzheimer type in the community: The utility of the clock drawing testArchives of Clinical Neuropsychology, 1996
- The Auditory-Verbal Learning Test (AVLT): Norms for ages 55 years and older.Psychological Assessment, 1990
- Development and validation of a geriatric depression screening scale: A preliminary reportJournal of Psychiatric Research, 1982
- Normative data on the boston diagnostic aphasia examination, parietal lobe battery, and the boston naming TestJournal of Clinical Neuropsychology, 1980
- “Mini-mental state”: A practical method for grading the cognitive state of patients for the clinicianJournal of Psychiatric Research, 1975
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960