Estimation of total-body and limb muscle mass in hemodialysis patients by using multifrequency bioimpedance spectroscopy
Open Access
- 1 November 2005
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 82 (5), 988-995
- https://doi.org/10.1093/ajcn/82.5.988
Abstract
Background: Skeletal muscle mass can be measured noninvasively with magnetic resonance imaging (MRI), but this is time-consuming and expensive. Objective: We evaluated the use of multifrequency bioimpedance spectroscopy (BIS) measurements of intracellular volume (ICV) to model total-body skeletal muscle mass (TBMM) and limb skeletal muscle mass in hemodialysis patients. Design: TBMM was measured by MRI in 20 male and 18 female hemodialysis patients with a median (range) age of 54 y (33–73 y), weight of 78.9 kg (43.2–120 kg), and body mass index (BMI; in kg/m2) of 27.3 (19.4–46.6). We measured total body water (TBW) by using D2O dilution, extracellular volume (ECV) as bromide space, and ICV as TBW minus bromide space. Total body potassium (TBK) measured as 40K was used as an independent model of TBMM. BIS was used to measure whole-body TBW (ankle to wrist) and TBW in the arms and legs. BIS-estimated ICV was used to construct models to calculate limb muscle mass and TBMM. The latter was compared with models derived from isotopic methods. Results: BIS yielded a model for TBMM [TBMM = 9.52 + 0.331 × ICV + 2.77 (male) + 0.180 × weight (kg) − 0.133 × age] (R2 = 0.937, P < 0.0001) as precise as TBK-measured TBMM [TBMM = 1.29 + 0.00453 × TBK (mEq) + 1.46 (male) + 0.144 × weight (kg) − 0.0565 × age] (R2 = 0.930, P < 0.0001) or isotopic methods. BIS models were also developed for measuring leg and arm muscle mass. Conclusion: BIS provides an estimate of TBMM that correlates well with isotopic methods in approximating values obtained by MRI and can be used to estimate limb muscle mass.Keywords
This publication has 29 references indexed in Scilit:
- Association of body size with outcomes among patients beginning dialysisThe American Journal of Clinical Nutrition, 2004
- Increased systemic and adipose tissue cytokines in patients with HIV-associated lipodystrophyAmerican Journal of Physiology-Endocrinology and Metabolism, 2004
- Body cell mass: model development and validation at the cellular level of body compositionAmerican Journal of Physiology-Endocrinology and Metabolism, 2004
- Effect of organ and tissue masses on resting energy expenditure in underweight, normal weight and obese adultsInternational Journal of Obesity, 2003
- Volume Estimates by Imaging Methods: Model Comparisons with Visible Woman as the ReferenceObesity Research, 2003
- Accuracy of an eight-point tactile-electrode impedance method in the assessment of total body waterEuropean Journal of Clinical Nutrition, 2002
- Body size, dose of hemodialysis, and mortalityAmerican Journal of Kidney Diseases, 2000
- Extracellular Water: Sodium Bromide Dilution Estimates Compared With Other Markers in Patients With Acquired Immunodeficiency SyndromeJournal of Parenteral and Enteral Nutrition, 1999
- Death Risk in Hemodialysis Patients: The Predictive Value of Commonly Measured Variables and an Evaluation of Death Rate Differences Between FacilitiesAmerican Journal of Kidney Diseases, 1990
- Resting Skeletal Muscle Membrane Potential as an Index of Uremic ToxicityJCI Insight, 1979