Body Size Indexes for Optimizing Iodine Dose for Aortic and Hepatic Enhancement at Multidetector CT: Comparison of Total Body Weight, Lean Body Weight, and Blood Volume
- 1 January 2010
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 254 (1), 163-169
- https://doi.org/10.1148/radiol.09090369
Abstract
Purpose To evaluate and compare total body weight (TBW), lean body weight (LBW), and estimated blood volume (BV) for the adjustment of the iodine dose required for contrast material–enhanced multidetector computed tomography (CT) of the aorta and liver. Materials and Methods Institutional review committee approval and written informed consent were obtained. One hundred twenty patients (54 men, 66 women; mean age, 64.1 years; range, 19–88 years) who underwent multidetector CT of the upper abdomen were randomized into three groups of 40 patients each: (a) TBW group (0.6 g of iodine per kilogram of TBW), (b) LBW group (0.821 g of iodine per kilogram of LBW), and (c) BV group (men, 8.6 g of iodine per liter of BV; women, 9.9 g of iodine per liter of BV). Change in CT number between unenhanced and contrast-enhanced images per gram of iodine and maximum hepatic enhancement (MHE) adjusted for iodine dose were examined for correlation with TBW, LBW, and BV by using linear regression analysis. Results In the portal venous phase, correlation coefficients for the correlation of change in CT number per gram of iodine with TBW for the aorta and liver were −0.71 and −0.79, respectively, in the TBW group; −0.80 and −0.86, respectively, in the LBW group; and −0.68 and −0.66, respectively, in the BV group. In the liver, they were marginally higher in the LBW group than in the BV group (P = .03). Adjusted MHE remained constant at 77.9 HU ± 10.2 (standard deviation) in the LBW group with respect to TBW, but it increased in the TBW (r = 0.80, P < .001) and BV (r = 0.70, P < .001) groups as TBW increased. Conclusion When LBW, rather than TBW or BV, is used, the iodine dose required to achieve consistent hepatic enhancement may be estimated more precisely and with reduced patient-to-patient variability. © RSNA, 2009Keywords
This publication has 21 references indexed in Scilit:
- Determining Contrast Medium Dose and Rate on Basis of Lean Body Weight: Does This Strategy Improve Patient-to-Patient Uniformity of Hepatic Enhancement during Multi–Detector Row CT?Radiology, 2007
- MDCT of the Liver and Hypervascular Hepatocellular Carcinomas: Optimizing Scan Delays for Bolus-Tracking Techniques of Hepatic Arterial and Portal Venous PhasesAmerican Journal of Roentgenology, 2006
- Optimizing Scan Delays of Fixed Duration Contrast Injection in Contrast-Enhanced Biphasic Multidetector-Row CT for the Liver and the Detection of Hypervascular Hepatocellular CarcinomaJournal of Computer Assisted Tomography, 2005
- Multi–Detector Row Helical CT in Preoperative Assessment of Small (≤1.5 cm) Liver Metastases: Is Thinner Collimation Better?Radiology, 2002
- Aortic and Hepatic Enhancement and Tumor-to-Liver Contrast: Analysis of the Effect of Different Concentrations of Contrast Material at Multi–Detector Row Helical CTRadiology, 2002
- Abdominal Helical CT: Evaluation of Optimal Doses of Intravenous Contrast Material—A Prospective Randomized StudyRadiology, 2000
- Effect of Injection Rate of Contrast Medium on Pancreatic and Hepatic Helical CTRadiology, 1999
- Aortic and hepatic contrast medium enhancement at CT. Part II. Effect of reduced cardiac output in a porcine model.Radiology, 1998
- Dynamic incremental CT: effect of volume and concentration of contrast material and patient weight on hepatic enhancement.Radiology, 1995
- Hepatic helical CT: contrast material injection protocol.Radiology, 1994