Disruption of KIF3A in patient-derived glioblastoma cells: effects on ciliogenesis, hedgehog sensitivity, and tumorigenesis

Abstract

// <![CDATA[ $('.header-date').hide();$('#titleAuthors').hide();$('#abstractHeader').hide(); // ]]> Lan B. Hoang-Minh1, 3, Loic P. Deleyrolle2, 3, Dorit Siebzehnrubl1, George Ugartemendia1, Hunter Futch2, Benjamin Griffith2, Joshua J. Breunig5- 9, Gabriel De Leon2, 4, Duane A. Mitchell2, 3, 4, Susan Semple-Rowland1, Brent A. Reynolds2, 3, Matthew R. Sarkisian1, 3 1Department of Neuroscience, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, Florida 2Department of Neurosurgery, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, Florida 3Preston A. Wells, Jr. Center for Brain Tumor Therapy, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, Florida 4UF Brain Tumor Immunotherapy Program, University of Florida College of Medicine, McKnight Brain Institute, Gainesville, Florida 5Cedars-Sinai Regenerative Medicine Institute, Cedar-Sinai Medical Center, Los Angeles, California 6Samuel Oschin Comprehensive Cancer Institute, Cedar-Sinai Medical Center, Los Angeles, California 7Division of Applied Cell Biology and Physiology, Cedar-Sinai Medical Center, Los Angeles, California 8Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 9Department of Medicine, UCLA Geffen School of Medicine, Los Angeles, California Correspondence to: Matthew R. Sarkisian, e-mail: msarkisian@ufl.edu Keywords: kinesin-2, brain tumor, cilium, intraflagellar transport, sonic hedgehog Received: July 08, 2015 Accepted: December 23, 2015 Published: January 09, 2016