Treatment of the Syndrome of Inappropriate Secretion of Antidiuretic Hormone with Furosemide

Abstract

IN the syndrome of inappropriate secretion of antidiuretic hormone (ADH), the basic water-restriction treatment^{1 , 2} can be difficult for the patient to endure. Demeclocycline³ or urea⁴ may then be tried. We treated a patient who had this syndrome without a known cause and who had symptomatic hyponatremia (seizures and confusion). He rapidly became intolerant to demeclocycline, and oral urea was contraindicated because of a history of severe peptic ulcer. Since intravenous furosemide with hypertonic saline is an efficient alternative for the rapid correction of hyponatremia in inappropriate secretion of ADH, ⁵ we treated the hyponatremia with long-term administration of oral furosemide; this . . .