Dietary ω-3 Fatty Acid and Fish Intake in the Primary Prevention of Age-Related Macular Degeneration
- 9 June 2008
- journal article
- research article
- Published by American Medical Association (AMA) in American Journal of Ophthalmology
- Vol. 126 (6), 826-833
- https://doi.org/10.1001/archopht.126.6.826
Abstract
Objective To systematically review the evidence on dietary ω-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration (AMD). Methods Seven databases were systematically searched with no limits on publication year or language using standardized criteria. Randomized controlled trials and prospective cohort, case-control, and cross-sectional studies were included. Of 2754 abstracts identified, 3 prospective cohort, 3 case-control, and 3 cross-sectional studies met the criteria. Measures of associations were pooled quantitatively using meta-analytic methods. Results Nine studies provided data on a total sample of 88 974 people, including 3203 AMD cases. A high dietary intake of ω-3 fatty acids was associated with a 38% reduction in the risk of late AMD (pooled odds ratio [OR], 0.62; 95% confidence interval [CI], 0.48-0.82). Fish intake at least twice a week was associated with a reduced risk of both early AMD (pooled OR, 0.76; 95% CI, 0.64-0.90) and late AMD (pooled OR, 0.67; 95% CI, 0.53-0.85). Conclusions Although this meta-analysis suggests that consumption of fish and foods rich in ω-3 fatty acids may be associated with a lower risk of AMD, there is insufficient evidence from the current literature, with few prospective studies and no randomized clinical trials, to support their routine consumption for AMD prevention.Keywords
This publication has 14 references indexed in Scilit:
- Eicosapentaenoic Acid Is Anti-Inflammatory in Preventing Choroidal Neovascularization in MiceInvestigative Ophthalmology & Visual Science, 2007
- Dietary fat and the risk of age-related maculopathy: the POLANUT StudyEuropean Journal of Clinical Nutrition, 2007
- Risk Factors for Five-Year Incident Age-related Macular Degeneration: The Reykjavik Eye StudyAmerican Journal of Ophthalmology, 2006
- Efficacy of ω-3 Fatty Acids in Preventing Age-Related Macular Degeneration: A Systematic ReviewOphthalmology, 2006
- Facts on fatsClinical & Experimental Ophthalmology, 2006
- Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic reviewBMJ, 2006
- Smoking and age-related macular degeneration: a review of associationEye, 2005
- The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retinaProgress in Retinal and Eye Research, 2004
- Measuring inconsistency in meta-analysesBMJ, 2003
- The prevalence of age-related maculopathy The visual impairment projectOphthalmology, 2000