Certain therapeutic effects upon the human organism ascribed to cocaine,∗ occasioned me to make use of the drug in suitable cases of psychosis and psycho-neurosis. Stimulant action and exhilaration (Euphoria) on the one hand, and on the other depression of undue sensitiveness, these were the effects I looked for from the alkaloid. Unfortunately, I am able to record scarcely a single case of certain and permanent cure following the use of the drug.