New insights into the pathogenesis ofStreptococcus pneumoniae-associated hemolytic uremic syndrome
- 1 September 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Pediatric Nephrology
- Vol. 35 (9), 1585-1591
- https://doi.org/10.1007/s00467-019-04342-3
Abstract
The purpose of this review is to describeStreptococcus pneumoniae-associated hemolytic uremic syndrome (P-HUS) with emphasis on new insights into the pathophysiology and management over the past 10 years. Even though awareness of this clinico-pathological entity has increased, it likely remains under-recognized. Recent observations indicate that although neuraminidase activity and exposure of the T-antigen are necessary for development of P-HUS, they are not sufficient; activation of the alternate pathway of complement may also contribute. It is unclear, however, whether or not eculizumab and/or plasmapheresis are of value.Keywords
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