Bayesian Multiple Quantitative Trait Loci Mapping for Complex Traits Using Markers of the Entire Genome
- 1 August 2007
- journal article
- Published by Oxford University Press (OUP) in Genetics
- Vol. 176 (4), 2529-2540
- https://doi.org/10.1534/genetics.106.064980
Abstract
A Bayesian methodology has been developed for multiple quantitative trait loci (QTL) mapping of complex binary traits that follow liability threshold models. Unlike most QTL mapping methods where only one or a few markers are used at a time, the proposed method utilizes all markers across the genome simultaneously. The outperformance of our Bayesian method over the traditional single-marker analysis and interval mapping has been illustrated via simulations and real data analysis to identify candidate loci associated with colorectal cancer.Keywords
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