HLA—Bw52 in Takayasu Disease
- 1 October 1978
- journal article
- Published by Wiley in Tissue Antigens
- Vol. 12 (4), 246-248
- https://doi.org/10.1111/j.1399-0039.1978.tb01332.x
Abstract
Takayasu disease is characterized by a pulseless condition which most often occurs in young females from Asian or South American areas. The cause of this disease remains obscure. Recently we encountered monozygotic, Japanese identical twin sisters, both of whom were diagnosed as having Takayasu disease. A genetically related factor was considered and HLA analysis was carried out. A population study on HLA typing analyses of 65 patients with Takayasu disease revealed a high frequency of HLA-B5 as compared with 128 healthy Japanese (chi2 :17.0, P less than 10(-4)). Subgroups of B5, Bw51 and Bw52 were successively studied in 82 patients with this disease. Bw51 antigen was found in 12.2% of patients with Takayasu disease and in 19.5% of 128 healthy Japanese. Contrarily, Bw52 antigen was confirmed in 43.9% of patients, a statistically significant frequency with the level of 26.5 in the chi2 test (cP less than 3 x 10(-4)) when compared with 12.5% in normal Japanese. Thus a genetically related factor in the pathogenesis of Takayasu disease has to be considered.Keywords
This publication has 11 references indexed in Scilit:
- Takayasu's disease in twin sisters. Possible genetic factors.Circulation, 1978
- Natural history and classification of occlusive thromboaortopathy (Takayasu's disease).Circulation, 1978
- The Joint Report of the Third Japan HLA WorkshopTissue Antigens, 1977
- HLA-D Antigens in the Japanese PopulationTissue Antigens, 1977
- The Association Between Genes in the Major Histocompatibility Complex and Disease SusceptibilityAnnual Review of Medicine, 1977
- Takayasu's arteritis. Clinical study of 107 casesAmerican Heart Journal, 1977
- A Study on HL-A System in JapaneseTissue Antigens, 1975
- Immunological Studies of Aortitis SyndromeJapanese Heart Journal, 1967
- Microdroplet Assay of Human Serum CytotoxinsNature, 1964
- Pulseless disease: A preliminary case reportAmerican Heart Journal, 1952