The Spanish version of Face-Name Associative Memory Exam (S-FNAME) performance is related to amyloid burden in Subjective Cognitive Decline
Open Access
- 28 February 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 8 (1), 1-9
- https://doi.org/10.1038/s41598-018-21644-y
Abstract
The Face-Name Associative Memory Exam (FNAME) is a paired associative memory test created to detect memory deficits in individuals with preclinical Alzheimer’s disease (AD). Worse performance on FNAME in cognitively healthy individuals were found related to higher amyloid beta (Aβ) burden measured with Positron-Emission-Tomography using 11C-PiB (PiB-PET). We previously reported normative data of a Spanish version of FNAME (S-FNAME) in cognitively healthy Spanish-speaking subjects. The aim of the present study was to determine whether performance on S-FNAME was associated with Aβ burden in subjective cognitive decline (SCD) individuals. 200 SCD subjects received neurological and neuropsychological assessments, including the S-FNAME and the Word List task from the Wechsler-Memory-Scale-III (WMS-III). Moreover, they received an MRI and (18)F-Florbetaben Positron-Emission-Tomography (FBB-PET) to measure Aβ burden. Three cognitive factor composites were derived for the episodic memory measures (face-name [SFN-N], face-occupation [SFN-O] and WMS-III) to determine whether episodic memory performance was related to Aβ deposition. Higher global Aβ deposition was significantly related to worse performance on SFN-N but not with SFN-O or WMS-III Composite. Moreover, worse SFN-N performance was significantly related to higher Aβ deposition in bilateral Posterior Cingulate Cortex. The S-FNAME may be a promising neuropsychological tool for detecting SCD individuals with preclinical AD.This publication has 52 references indexed in Scilit:
- Promising developments in neuropsychological approaches for the detection of preclinical Alzheimer’s disease: a selective reviewAlzheimer's Research & Therapy, 2013
- Cut-off Scores of a Brief Neuropsychological Battery (NBACE) for Spanish Individual Adults Older than 44 Years OldPLOS ONE, 2013
- Subjective cognitive complaints and amyloid burden in cognitively normal older individualsNeuropsychologia, 2012
- Normative data of a brief neuropsychological battery for Spanish individuals older than 49Journal of Clinical and Experimental Neuropsychology, 2012
- Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s diseaseEuropean Journal of Nuclear Medicine and Molecular Imaging, 2012
- Face-name associative memory performance is related to amyloid burden in normal elderlyNeuropsychologia, 2011
- Posterior cingulate cortex: adapting behavior to a changing worldTrends in Cognitive Sciences, 2011
- Alzheimer's diseaseThe Lancet, 2006
- Distinguishing normal and demented elderly with the selective reminding testJournal of Clinical and Experimental Neuropsychology, 1989
- The Hospital Anxiety and Depression ScaleActa Psychiatrica Scandinavica, 1983