Mutations in BMPR-IB and BMP-15 genes are associated with litter size in Small Tailed Han sheep (Ovis aries)1
- 1 March 2007
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Animal Science
- Vol. 85 (3), 598-603
- https://doi.org/10.2527/jas.2006-324
Abstract
The Small Tailed Han is a prolific local sheep breed in China. The bone morphogenetic protein receptor IB (BMPR-IB) gene, which affects the fecundity of Booroola Merino sheep, and the bone morphogenetic protein 15 (BMP-15) gene, which affects the fecundity of Inverdale, Hanna, Belclare, Cambridge, and Lacaune sheep, were studied as candidate genes associated with the prolificacy of Small Tailed Han sheep. Single nucleotide polymorphisms of BMPR-IB and BMP-15 genes were detected in Small Tailed Han ewes (n = 188) by PCR-RFLP. The combined effect of the 2 genes on the prolificacy of Small Tailed Han sheep was studied. The results indicated that the same FecB mutation (Q249R) occurred in the BMPR-IB gene in Small Tailed Han ewes as found in Booroola Merino ewes. The Small Tailed Han ewes with genotypes FecBB/FecBB and FecBB/FecB+ had 1.40 (P < 0.01) and 1.11 (P < 0.01) more lambs, respectively, than those with genotype FecB+/FecB+. The same FecXG mutation (Q239Ter) of the BMP-15 gene was found in Small Tailed Han ewes as in Belclare and Cambridge ewes. The Small Tailed Han ewes with the heterozygous mutant FecXG/FecX+ had 0.55 (P < 0.01) more lambs than those with the wild-type FecX+/FecX+. The Small Tailed Han ewes carrying mutations in both BMPR-IB and BMP-15 genes had greater litter size than those with either mutation alone. In view of our results, marker-assisted selection using both BMPR-IB and BMP-15 genes is warranted to increase litter size in sheep and will be of considerable economic value to sheep producers.Keywords
This publication has 18 references indexed in Scilit:
- Investigation of the Booroola (FecB) and Inverdale (FecXI) mutations in 21 prolific breeds and strains of sheep sampled in 13 countriesAnimal Reproduction Science, 2006
- Polymorphism of FecB Gene in Nine Sheep Breeds or Strains and Its Effects on Litter Size, Lamb Growth and DevelopmentYi chuan xue bao = Acta genetica Sinica, 2006
- Association of Single Nucleotide Polymorphisms in Exon 6 Region of BMPRIB Gene with Litter Size Traits in SheepAsian-Australasian Journal of Animal Sciences, 2005
- Mutations in the Genes for Oocyte-Derived Growth Factors GDF9 and BMP15 Are Associated with Both Increased Ovulation Rate and Sterility in Cambridge and Belclare Sheep (Ovis aries)1Biology of Reproduction, 2004
- Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa CellsPublished by Elsevier BV ,2003
- Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 Are Essential for Ovarian Follicular Development in Sheep1Biology of Reproduction, 2002
- DNA Tests in Prolific Sheep from Eight Countries Provide New Evidence on Origin of the Booroola (FecB) Mutation1Biology of Reproduction, 2002
- Mutations in an oocyte-derived growth factor gene (BMP15) cause increased ovulation rate and infertility in a dosage-sensitive mannerNature Genetics, 2000
- Ovaries of Ewes Homozygous for the X-Linked Inverdale Gene (FecXI) are Devoid of Secondary and Tertiary Follicles but Contain Many Abnormal StructuresBiology of Reproduction, 1993
- Infertility Due to Bilateral Ovarian Hypoplasia in Sheep Homozygous (FecX1 FecX1) for the Inverdale Prolificacy Gene Located on the X ChromosomeBiology of Reproduction, 1992