Severity of Leukoaraiosis and Susceptibility to Infarct Growth in Acute Stroke
- 1 May 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 39 (5), 1409-1413
- https://doi.org/10.1161/strokeaha.107.501932
Abstract
Background and Purpose— Leukoaraiosis (LA) is associated with structural and functional vascular changes that may compromise tissue perfusion at the microvascular level. We hypothesized that the volume of LA correlated with the proportion of initially ischemic but eventually infarcted tissue in acute human stroke. Methods— We studied 61 consecutive patients with diffusion-weighted imaging–mean transit time mismatch. All patients were scanned twice within 12 hours of symptom onset and between days 4 and 30. We explored the relationship between the volume of white matter regions with LA on acute images and the proportion of diffusion-weighted imaging–mean transit time mismatch tissue that progressed to infarction (percentage mismatch lost). Results— Bivariate analyses showed a statistically significant correlation between percentage mismatch lost and LA volume ( r =0.33, P P =0.04). The adjusted percentage mismatch lost in the highest quartile of LA volume was 1.9-fold (95% CI: 1.2 to 3.1) greater than the percentage mismatch lost in the lowest quartile. Conclusion— LA volume at the time of acute ischemic stroke is a predictor infarct growth. Because LA is associated with factors that modulate tissue perfusion as well as tissue capacity for handling of ischemia, LA volume appears to be a composite predictive marker for the fate of acutely ischemic tissue.This publication has 31 references indexed in Scilit:
- Validation of Intracranial Area as a Surrogate Measure of Intracranial Volume When Using Clinical MRIJournal of Neuroimaging, 2007
- Age, Hypertension, and Lacunar Stroke Are the Major Determinants of the Severity of Age-Related White Matter ChangesCerebrovascular Diseases, 2006
- Conversion of Ischemic Brain Tissue Into Infarction Increases With AgeStroke, 2005
- An evidence‐based causative classification system for acute ischemic strokeAnnals of Neurology, 2005
- Intracranial Area: A Validated Method for Estimating Intracranial VolumeJournal of Neuroimaging, 2005
- Heritability of Leukoaraiosis in Hypertensive SibshipsHypertension, 2004
- Ischemic injury in experimental stroke depends on angiotensin IIThe FASEB Journal, 2001
- Larger Anastomoses in Angiotensinogen-Knockout Mice Attenuate Early Metabolic Disturbances after Middle Cerebral Artery OcclusionJournal of Cerebral Blood Flow & Metabolism, 1999
- High resolution measurement of cerebral blood flow using intravascular tracer bolus passages. Part I: Mathematical approach and statistical analysisMagnetic Resonance in Medicine, 1996
- Cerebral circulation and oxygen metabolism associated with subclinical periventricular hyperintensity as shown by magnetic resonance imagingAnnals of Neurology, 1990