Increased Frequency of HL‐A8 in Sjogren's Syndrome

Abstract
The histocompatibility antigen, HL‐A8, was found to be elevated in patients with Sjogren's syndrome. Among 24 patients, the frequency of HL‐A8 was 58% compared to 21% among controls (P < 0.001 after correction). With the addition of this disorder to the list of other autoimmune diseases associated with HL‐A8, it now seems possible to postulate a single basis autoimmune defect gene in high linkage disequilibrium with HL‐A8.