How to best define the metabolic syndrome
- 1 January 2006
- journal article
- review article
- Published by Informa UK Limited in Annals of Medicine
- Vol. 38 (1), 34-41
- https://doi.org/10.1080/07853890500300311
Abstract
The constellation of metabolic abnormalities including centrally distributed obesity, decreased high‐density lipoprotein cholesterol (HDL‐C), elevated triglycerides, elevated blood pressure (BP), and hyperglycaemia is known as the metabolic syndrome. Associated with increased risk of both type 2 diabetes and cardiovascular disease (CVD), the metabolic syndrome is thought to be a driver of the modern day epidemics of diabetes and CVD and has become a major public health challenge around the world . Since its initial description, several definitions of the syndrome have emerged. Each of these definitions used differing sets of criteria, the combination of which either reflected contrasting views on pathogenic mechanisms or clinical usefulness. The use of these definitions to conduct research into the metabolic syndrome in diverse populations resulted in wide ranging prevalence rates, inconsistencies and confusion, and spurred on the vigorous debate regarding how the metabolic syndrome should be defined. In response to this controversy, the International Diabetes Federation (IDF) has recently proposed a new definition, which is applicable to populations around the world . It is envisaged that the development of the new definition for the metabolic syndrome will help resolve the confusion caused by the number of earlier attempts to define this important entity.Keywords
This publication has 26 references indexed in Scilit:
- The Metabolic Syndrome: A Concept Hard to DefineArchives of Medical Research, 2005
- The metabolic syndromeThe Lancet, 2005
- Adiponectin, the missing link in insulin resistance and obesityClinical Nutrition, 2004
- Components of the “Metabolic Syndrome” and Incidence of Type 2 DiabetesDiabetes, 2002
- Role of Adiponectin in Preventing Vascular StenosisJournal of Biological Chemistry, 2002
- Adiponectin - Its Role in Metabolism and BeyondHormone and Metabolic Research, 2002
- Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)JAMA, 2001
- Etiology of the Metabolic Syndrome: Potential Role of Insulin Resistance, Leptin Resistance, and Other PlayersAnnals of the New York Academy of Sciences, 1999
- Comment on the provisional report from the WHO consultationDiabetic Medicine, 1999
- Role of Insulin Resistance in Human DiseaseDiabetes, 1988