Post-translational regulation of lipoprotein lipase activity in adipose tissue
- 15 December 1978
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 176 (3), 865-872
- https://doi.org/10.1042/bj1760865
Abstract
Changes in adipose-tissue lipoprotein lipase activity that are independent of protein synthesis were investigated in an incubation system in vitro. Under appropriate conditions at 25 degrees C a progressive increase in the enzyme activity occurs that is energy-dependent. Part of the enzyme is rapidly inactivated when the tissue is incubated with adrenaline or adrenaline plus theophylline. The mechanism of this inactivation appears to be distinct from, and to follow, the activation of the enzyme. A hypothesis is presented to account for the results in terms of an activation of the enzyme during obligatory post-translational processing and a catecholamine-regulated inactivation of the enzyme as an alternative to secretion from the adipocyte.This publication has 30 references indexed in Scilit:
- The heterogeneity of the lipoprotein lipase of rat epididymal adipose tissueBiochemical Journal, 1978
- Hormone-sensitive lipase of adipose tissue.1977
- Stimulatory action of cycloheximide on glucose metabolism in the rat epididymal fat padJournal of Lipid Research, 1977
- The role of organelles in the chemical modification of the primary translation products of secretory proteinsFEBS Letters, 1976
- Lipoprotein lipase from bovine milk. Isolation procedure, chemical characterization, and molecular weight analysisJournal of Biological Chemistry, 1976
- Purification and Characterization of Lipoprotein Lipase from Pig Adipose TissueJournal of Biological Chemistry, 1974
- Regulation of fatty-acid synthesis in higher animalsPublished by Springer Science and Business Media LLC ,1974
- Stimulation by Growth Hormone and Dexamethasone of Labeled Cyclic Adenosine 3',5'-Monophosphate Accumulation by White Fat CellsJournal of Biological Chemistry, 1970
- Adenosine 3',5'-monophosphate in biological materials. II. The measurement of adenosine 3',5'-monophosphate in tissues and the role of the cyclic nucleotide in the lipolytic response of fat to epinephrine.1965
- An enzymic method for the estimation of glycerol in blood and its use to determine the effect of noradrenaline on the concentration of glycerol in blood.1962