An analysis of the dependence of weight index (WI), cholesterol, triglyceride levels or lipoprotein phenotypes on the extent of coronary artery lesions was carried out in 90 patients with angiographically established coronary artery disease. Close relationships were revealed between cholesterol levels and atherosclerotic lesions as well as an enhanced incidence of lesions in types II and IV of hyperliproteinaemia. No relationships could be detected between the Wl, triglyceride levels, and atherosclerosis. Conclusions are drawn as to the time of prophylaxis onset in types II and IV hyperlipoproteinaemic subjects and its main direction.