Stat3 is essential for neuronal differentiation through direct transcriptional regulation of the Sox6 gene
- 19 November 2010
- journal article
- Published by Wiley in FEBS Letters
- Vol. 585 (1), 148-152
- https://doi.org/10.1016/j.febslet.2010.11.030
Abstract
The transcription factor Signal Transducer and Activator of Transcription 3 (Stat3) functions in various cellular processes including neuronal differentiation. We show that the SRY-box containing gene 6 (Sox6) gene, important for neuronal differentiation, is a direct target gene of Stat3. We demonstrate that in response to ligand stimulation, Stat3 binds to the Sox6 promoter and induces its expression. Furthermore, Stat3 is activated and Sox6 is induced during neuronal differentiation of P19 cells in the absence of exogenous ligand treatment. Moreover, using an RNA interference approach, we show that Stat3 is required for Sox6 expression during neuronal differentiation.This publication has 16 references indexed in Scilit:
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