Role of Interleukin-6 as an Early Marker of Fat Embolism Syndrome: A Clinical Study
- 1 July 2013
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Orthopaedics and Related Research
- Vol. 471 (7), 2340-2346
- https://doi.org/10.1007/s11999-013-2869-y
Abstract
A few animal studies have shown that IL-6 can serve as an early marker of fat embolism syndrome. The degree to which this is true in human trauma victims is unknown. In this clinical study, we sought to determine (1) whether elevated serum IL-6 levels at 6, 12, and 24 hours in patients with skeletal trauma were associated with the development of fat embolism syndrome (FES) within 72 hours after injury, and (2) at what time after trauma peak IL-6 levels are observed. Forty-eight patients between 16 and 40 years old who presented to our tertiary trauma center within 6 hours of injury with long bone and/or pelvic fractures were included in this study. Serum IL-6 levels were measured at 6, 12, and 24 hours after injury. The patients were observed clinically and monitored for 72 hours for development of FES symptoms. Gurd’s criteria were used to diagnose FES. Elevated serum IL-6 levels 12 hours after trauma correlated with an increased likelihood of having FES develop; no significant relationship was observed between IL-6 levels at 6 or 24 hours and the development of FES. Patients with FES had a mean IL-6 level of 131 pg/mL, whereas those without FES had a mean IL-6 level of 72 pg/mL. Peak IL-6 levels were observed at 12 hours. An elevated serum IL-6 level may be useful as an early marker of FES in patients with isolated skeletal trauma. Level II, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.Keywords
This publication has 34 references indexed in Scilit:
- Analyzing fat embolism syndrome in trauma patients at AIIMS Apex Trauma Center, New Delhi, IndiaJournal of Emergencies, Trauma, and Shock, 2011
- An arrowhead found incidentally in the chest during workup for unrelated disease after 22-years of initial injuryJournal of Emergencies, Trauma, and Shock, 2011
- Correlation of measurable serum markers of inflammation with lung levels following bilateral femur fracture in a rat modelJournal of Inflammation Research, 2010
- Interleukin-6 as an early marker for fat embolismJournal of Orthopaedic Surgery and Research, 2009
- Stratification is the key: Inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis*Critical Care Medicine, 2009
- Review Systemic Effects of Femoral NailingClinical Orthopaedics and Related Research, 2002
- Major Secondary Surgery in Blunt Trauma Patients and Perioperative Cytokine Liberation: Determination of the Clinical Relevance of Biochemical MarkersThe Journal of Trauma and Acute Care Surgery, 2001
- Stimulation of the inflammatory system by reamed and unreamed nailing of femoral fracturesThe Journal of Bone and Joint Surgery. British volume, 1999
- Sequential Appearance of Inflammatory Mediators in Rat Bronchoalveolar Lavage Fluid After Oleic Acid-Induced Lung InjuryExperimental Lung Research, 1996
- Fat EmbolismClinical Orthopaedics and Related Research, 1988