Free Radical Chemistry
- 1 March 1988
- journal article
- review article
- Published by Springer Science and Business Media LLC in Sports Medicine
- Vol. 5 (3), 156-170
- https://doi.org/10.2165/00007256-198805030-00003
Abstract
Free radicals are molecules or molecular fragments containing an unpaired electron in the valence shell. Radicals interested only a few chemists until 18 years ago when an enzyme was discovered which functioned to remove a specific oxygen-centered radical. That discovery renewed interest in radicals and has already begun to alter thinking on many clinical problems. Free radicals have been shown to be common phenomena that play a role in normal biochemistry but require an elaborate control system to be held in check. Since oxygen-centered radicals are produced in intermediate metabolism, exercise should increase their production and that has been shown to be so. There is also evidence that the consumption of large quantities of ambient oxygen during exercise induces harmful chemistry known as lipid peroxidation. Presently, there are insufficient data available to ascertain how the human body tolerates such increased production of free radicals and lipid peroxidation and how the consequences of that chemistry might relate to the overall well being of exercising humans.Keywords
This publication has 72 references indexed in Scilit:
- Exercise and MalignancySports Medicine, 1986
- Oxygen-Derived Free Radicals in Postischemic Tissue InjuryNew England Journal of Medicine, 1985
- Endurance training and antioxidants of lungCellular and Molecular Life Sciences, 1984
- Disorder in human myelin induced by superoxide radical: An investigationBiochemical and Biophysical Research Communications, 1983
- Free radicals and tissue damage produced by exerciseBiochemical and Biophysical Research Communications, 1982
- Effect of disuse on the skeletal muscle catalase of ratsBiochemical Medicine, 1982
- Cell division in normal and transformed cells: The possible role of superoxide and hydrogen peroxideMedical Hypotheses, 1981
- Catalase activity in skeletal muscle of varying fibre typesCellular and Molecular Life Sciences, 1981
- Catalase activity in electrically stimulated muscleCellular and Molecular Life Sciences, 1980
- Catalase Levels and Radiation Resistance in Three Species of Wild DuckInternational Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine, 1969