Relationship between leucocytosis and left ventricular ejection fraction in patients with acute myocardial infarction
- 15 January 2013
- journal article
- Published by Medknow in Singapore Medical Journal
- Vol. 54 (1), 40-43
- https://doi.org/10.11622/smedj.2013010
Abstract
Myocardial infarction (MI) is common and affects a significant number of people annually. Death occurs due to either arrhythmia or heart failure. As leucocytosis, especially elevated neutrophil count, is a hallmark of inflammatory reactions in patients with MI, we investigated the relationship between leucocytosis on admission and left ventricular ejection fraction (LVEF) in patients with acute MI (AMI). Patients with AMI were enrolled in a case-control study. Blood samples obtained in the first 24 hours after the onset of pain were analysed for cardiac enzyme levels and cell count. Echocardiography was performed on Days 3-5. Patients with LVEF < 45% were assigned to the left ventricular (LV) systolic dysfunction group (n = 69) and those with LVEF ≥ 45% were taken as controls (n = 69). All patients were matched for variables such as hypertension, diabetes mellitus, hyperlipidaemia, family history of cardiac disease, age and gender. Leucocytosis was higher in patients with systolic dysfunction (47.8%) when compared with the controls (20.3%), and was significantly associated with the development of LV systolic dysfunction (p = 0.001). Similarly, neutrophilia was more common in patients with systolic dysfunction than the controls (6.6% vs. 34.8%), and was significantly associated with LV systolic dysfunction (p < 0.001). Monocytosis was higher in the controls than the systolic dysfunction group (40.6% vs. 33.3%; p = 0.378). Leucocytosis and neutrophilia in the acute phase of MI are important predictive factors for the development of LV systolic dysfunction. Leucocytosis can be used for risk stratification of such patients.Keywords
This publication has 10 references indexed in Scilit:
- Leukocytic DisordersPublished by Elsevier BV ,2011
- Leukocytosis as a predictor for non-infective mortality and morbidityQJM: An International Journal of Medicine, 2010
- Neutrophilia Predicts Death and Heart Failure After Myocardial InfarctionCirculation: Cardiovascular Quality and Outcomes, 2009
- Influência de leucócitos e glicemia no prognóstico de pacientes com infarto agudo do miocárdioArquivos Brasileiros de Cardiologia, 2009
- Leukocytosis and Ischemic Vascular Disease Morbidity and MortalityArteriosclerosis, Thrombosis, and Vascular Biology, 2005
- Leukocyte count and coronary heart diseaseJournal of the American College of Cardiology, 2004
- White blood cell count and long term mortality after non-ST elevation acute coronary syndrome treated with very early revascularisationHeart, 2003
- Relationship between baseline white blood cell count and degree of coronary artery disease and mortality in patients with acute coronary syndromesJournal of the American College of Cardiology, 2002
- Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectorisThe American Journal of Cardiology, 2001
- Role of Neutrophils in Myocardial Ischemia and ReperfusionCirculation, 1995