Large cell neuroendocrine carcinoma of the uterine cervix: a report of a case with coexisting cervical intraepithelial neoplasia and human papillomavirus 16
- 1 January 1999
- journal article
- case report
- Published by Elsevier BV in Pathology
- Vol. 31 (2), 158-161
- https://doi.org/10.1080/003130299105368
Abstract
Summary Large cell neuroendocrine carcinomas (LCNECs), one of the four newly categorised endocrine tumors of the uterine cervix, are unusual and aggressive tumors. The present report describes a case of LCNEC diagnosed at an early stage and associated with cervical intraepithelial neoplasia (CIN). The LCNEC showed organoid and trabecular growth patterns and was positive for chromogranin and synaptophysin. The CIN lesion was of a high grade and was negative for these neuroendocrine markers. Polymerase chain reaction (PCR) using genomic DNA extracted from archival tissue demonstrated human papillomavirus (HPV) type 16 DNA in both the LCNEC and CIN lesions. These histological, immunohistochemical and PCR findings suggested that the LCNEC lesion was distinct from the CIN lesion and that both resulted from the carcinogenic field effect of HPV 16.Keywords
This publication has 5 references indexed in Scilit:
- Small Cell Carcinoma of the CervixObstetrical & Gynecological Survey, 1994
- Small-Cell Carcinoma of the EndometriumThe American Journal of Surgical Pathology, 1994
- Small cell carcinoma of the cervix. A clinicopathologic study of 26 patientsCancer, 1994
- Small-Cell Neuroendocrine Carcinoma of the CervixThe American Journal of Surgical Pathology, 1991
- Amplification and Specific Detection of Transforming Gene Region of Human Papillomavirus 16, 18 and 33 in Cervical Carcinoma by Means of the Polymerase Chain ReactionJapanese Journal of Cancer Research, 1990