Exploring the role of context‐dependent hippocampal activity in spatial alternation behavior
- 6 June 2007
- journal article
- research article
- Published by Wiley in Hippocampus
- Vol. 17 (10), 988-1002
- https://doi.org/10.1002/hipo.20301
Abstract
In a continuous T‐maze spatial alternation task, CA1 place cells fire differentially on the stem of the maze as rats are performing left‐ and right‐turn trials (Wood et al. (2000) Neuron 27:623–633). This context‐dependent hippocampal activity provides a potential mechanism by which animals could solve the alternation task, as it provides a cue that could prime the appropriate goal choice. The aim of this study was to examine the relationship between context‐dependent hippocampal activity and spatial alternation behavior. We report that rats with complete lesions of the hippocampus learn and perform the spatial alternation task as well as controls if there is no delay between trials, suggesting that the observed context‐dependent hippocampal activity does not mediate alternation behavior in this task. However lesioned rats are significantly impaired when delays of 2 or 10 s are interposed. Recording experiments reveal that context‐dependent hippocampal activity occurs in both the delay and no‐delay versions of the task, but that in the delay version it occurs during the delay period, and not on the stem of the maze. These data are consistent with a role for context‐dependent hippocampal activity in delayed spatial alternation, but suggest that, according to specific task demands and memory load, the activity may be generated by different mechanisms and/or in different brain structures.Keywords
This publication has 48 references indexed in Scilit:
- Conjunctive effects of reward and behavioral episodes on hippocampal place-differential neurons of rats on a mobile treadmillHippocampus, 2006
- Sequential-Context-Dependent Hippocampal Activity Is Not Necessary to Learn Sequences with Repeated ElementsJournal of Neuroscience, 2005
- Heterogeneous Modulation of Place Cell Firing by Changes in ContextJournal of Neuroscience, 2003
- Dynamics of Population Code for Working Memory in the Prefrontal CortexNeuron, 2003
- Longitudinal axis of the hippocampus: Both septal and temporal poles of the hippocampus support water maze spatial learning depending on the training protocolHippocampus, 2003
- Neurotoxic Hippocampal Lesions Have No Effect on Odor Span and Little Effect on Odor Recognition Memory But Produce Significant Impairments on Spatial Span, Recognition, and AlternationJournal of Neuroscience, 2000
- The Hippocampus, Memory, and Place Cells: Is It Spatial Memory or a Memory Space?Neuron, 1999
- Sustained activation of hippocampal pyramidal cells by ‘space clamping’ in a running wheelEuropean Journal of Neuroscience, 1999
- Cue-sampling and goal-approach correlates of hippocampal unit activity in rats performing an odor-discrimination taskJournal of Neuroscience, 1987
- The effects of hippocampal lesions upon spatial and non-spatial tests of working memoryBehavioural Brain Research, 1986