On the Origin of Event-Related Potentials Indexing Covert Attentional Selection During Visual Search
- 1 October 2009
- journal article
- research article
- Published by American Physiological Society in Journal of Neurophysiology
- Vol. 102 (4), 2375-2386
- https://doi.org/10.1152/jn.00680.2009
Abstract
Despite nearly a century of electrophysiological studies recording extracranially from humans and intracranially from monkeys, the neural generators of nearly all human event-related potentials (ERPs) have not been definitively localized. We recorded an attention-related ERP component, known as the N2pc, simultaneously with intracranial spikes and local field potentials (LFPs) in macaques to test the hypothesis that an attentional-control structure, the frontal eye field (FEF), contributed to the generation of the macaque homologue of the N2pc (m-N2pc). While macaques performed a difficult visual search task, the search target was selected earliest by spikes from single FEF neurons, later by FEF LFPs, and latest by the m-N2pc. This neurochronometric comparison provides an empirical bridge connecting macaque and human experiments and a step toward localizing the neural generator of this important attention-related ERP component.Keywords
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