Estrogen and progesterone replacement therapy reduces low density lipoprotein accumulation in the coronary arteries of surgically postmenopausal cynomolgus monkeys.
Open Access
- 1 December 1991
- journal article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 88 (6), 1995-2002
- https://doi.org/10.1172/jci115526
Abstract
The effect of estrogen and progesterone replacement therapy on the initiating events in atherogenesis was studied in surgically postmenopausal cynomolgus monkeys. Monkeys were ovariectomized and divided randomly into two groups, one receiving 17 beta-estradiol and cyclic progesterone treatment (n = 9) and ovariectomized controls receiving no hormone replacement therapy (n = 8). The monkeys were fed a moderately atherogenic diet for 18 wk to accelerate the early pathogenic processes but not to be of sufficient duration to produce grossly visible atherosclerotic lesions. Sex hormone replacement therapy decreased the accumulation of LDL and products of LDL degradation in the coronary arteries by greater than 70% while having no significant effect on plasma lipid, lipoprotein, or apoprotein concentrations. Arterial intimal lesions were small with no difference between groups. The reduction in arterial LDL metabolism occurred very early in the pathogenesis of atherosclerosis and was independent of indices of endothelial cell injury, such as enhanced endothelial cell turnover or leukocyte adhesion to the endothelium. Results of this study suggest that one mechanism by which sex hormone treatment inhibits the initiation of atherosclerosis is a direct effect at the level of the arterial wall by suppressing the uptake and/or degradation of LDL.This publication has 41 references indexed in Scilit:
- The arterial barrier to lipoprotein influx in the hypercholesterolemic rabbit: 2. Long-term studies in deendothelialized and reendothelialized aortasAtherosclerosis, 1989
- Contraceptive steroid effects on lipids and lipoproteins in cynomolgus monkeys.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1989
- Sex, plasma lipoproteins, and atherosclerosis: Prevailing assumptions and outstanding questionsAmerican Heart Journal, 1987
- Psychosocial influences on ovarian endocrine and ovulatory function in Macaca fascicularisPhysiology & Behavior, 1985
- LDL Heterogeneity and Atherosclerosis in Nonhuman PrimatesaAnnals of the New York Academy of Sciences, 1985
- Ovariectomy, social status, and atherosclerosis in cynomolgus monkeys.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985
- Psychosocial influences on female ‘protection’ among cynomolgus macaquesAtherosclerosis, 1984
- MEtabolism by cells in culture of low-density lipoproteins of abnormal composition from non-human primates with diet-induced hypercholesterolemiaBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980
- The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observationsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
- A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATIONCanadian Journal of Biochemistry and Physiology, 1959