CYCLICITY IN INTERRELATIONSHIPS BETWEEN PLASMA INSULIN AND GLUCOSE DURING STARVATION IN NORMAL YOUNG MEN

  • 1 January 1968
    • journal article
    • research article
    • Vol. 71 (1), 171-+
Abstract
Plasma specimens were secured from 11 healthy young men at 7-8 AM and 3-4 PM during 3 to 4 days of total starvation and analyzed for immunoreactive insulin (IRI) and glucose. Diurnal patterns for plasma glucose could not be demonstrated. However, IRI levels were significantly greater in the AM than the PM throughout the fast so that the early morning ratios for IRI/glucose exceeded the midafternoon values. The findings have been interpreted as consistent with some rhythmic cyclicity for insulin secretion which is intrinsically determined and can be sustained without exogenous stimuli to insulinogenesis.