"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.
- 1 August 1993
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 90 (15), 6909-6913
- https://doi.org/10.1073/pnas.90.15.6909
Abstract
Solid-phase chemistry, organic synthesis, and an apparatus for multiple, simultaneous synthesis have been combined to generate libraries of organic compounds ("diversomers"). Arrays of compounds were synthesized over two to three steps incorporating chemically diverse building blocks on a polystyrene-based solid support in a multiple, simultaneous manner. The generality of this approach is illustrated by the syntheses of dipeptides, hydantoins, and benzodiazepines.Keywords
This publication has 9 references indexed in Scilit:
- Peptoids: a modular approach to drug discovery.Proceedings of the National Academy of Sciences of the United States of America, 1992
- Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesisProceedings of the National Academy of Sciences of the United States of America, 1992
- Light-Directed, Spatially Addressable Parallel Chemical SynthesisScience, 1991
- Peptides on phage: a vast library of peptides for identifying ligands.Proceedings of the National Academy of Sciences of the United States of America, 1990
- Random Peptide Libraries: a Source of Specific Protein Binding MoleculesScience, 1990
- Searching for Peptide Ligands with an Epitope LibraryScience, 1990
- Examination of the secondary structure of proteins by deconvolved FTIR spectraPeptide Science, 1986
- 1-Azacycloalkyl-1,4-benzodiazepin-2-ones with antianxiety-antidepressant actionsJournal of Medicinal Chemistry, 1985
- p-Alkoxybenzyl Alcohol Resin and p-Alkoxybenzyloxycarbonylhydrazide Resin for Solid Phase Synthesis of Protected Peptide FragmentsJournal of the American Chemical Society, 1973