Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3ɛ
- 11 August 2009
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Signaling
- Vol. 2 (83), ra43
- https://doi.org/10.1126/scisignal.2000402
Abstract
A mutant CD3ɛ subunit that cannot change conformation in response to ligand binding exerts dominant-negative inhibition of T cell responses.Keywords
This publication has 41 references indexed in Scilit:
- Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell ReceptorImmunity, 2009
- Critical and Multiple Roles for the CD3ε Intracytoplasmic Tail in Double Negative to Double Positive Thymocyte DifferentiationThe Journal of Immunology, 2009
- Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based MotifCell, 2008
- T Cell Receptor Engagement Triggers Its CD3ε and CD3ζ Subunits to Adopt a Compact, Locked ConformationPLOS ONE, 2008
- How the “Melting” and “Freezing” of Protein Molecules May Be Used in Cell SignalingACS Chemical Biology, 2008
- The CXXC motif at the N terminus of an α‐helical peptideProtein Science, 2006
- A conformational change senses the strength of T cell receptor–ligand interaction during thymic selectionProceedings of the National Academy of Sciences of the United States of America, 2006
- How well does a restrained electrostatic potential (RESP) model perform in calculating conformational energies of organic and biological molecules?Journal of Computational Chemistry, 2000
- T cell receptor antagonist peptides induce positive selectionCell, 1994
- Comparison of simple potential functions for simulating liquid waterThe Journal of Chemical Physics, 1983